Dead Rising 2 starts several years after the original Dead Rising finished: the experimental virus that turns living beings into the undead has spread beyond Willamette and infested most of the United States. When the crisis became serious, a synthetic drug called “Zombrex” which delays the zombification was released by the pharmaceutical company Phenotrans and sold out quickly.
The player takes control over Chuck Greene, a former national motocross champion fleeing to Fortune City, rebuilt from the remains of old Las Vegas and yet untouched by the zombie disease, along with his daughter Katey. Katey was bitten by her zombified mother and thus needs a shot of Zombrex every 24 hours to avoid zombification. In order to get his hands on more Zombrex – or at least the money to buy some – Chuck is desperate enough to enter a game show called “Terror Is Reality” where he has to slay the undead for entertainment. Right after the show some of his “victims” break loose into the city, causing a wide-scale infection. Chuck learns from a news report that he is accused of causing the outbreak and that the military will come to capture him and to purge the city in three days.